Research output per year
Research output per year
- 35 results
Search results
-
2023
A comparison of the Netherlands, Norway, and UK Familial Hypercholesterolemia screening programmes with implications for target setting and the UK’s NHS Long Term Plan
Page, C., Zheng, H., Wang, H., Rai, T. S., O'Kane, M., Hart, P., McKee, S. & Watterson, S., 25 Apr 2023, (Published online) In: PLOS Global Public Health. 3, 4, 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
2022
Immuno-informatics analysis predicts B and T cell consensus epitopes for designing peptide vaccine against SARS-CoV-2 with 99.82% global population coverage
Shukla, P., Pandey, P., Prasad, B., Robinson, T., Purohit, R., D'Cruz, L. G., Tambuwala, M., Mutreja, A., Harkin, J., Rai, T. S., Murray, EK., Gibson, D. S. & Bjourson, AJ., 1 Jan 2022, In: Briefings in Bioinformatics. 23, 1, p. 1-15 15 p., bbab496.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)43 Downloads (Pure) -
Precision medicine to manage chronic immune-related conditions
Gibson, D., Egan, P., Guo, G., Kelly, C., McClean, P., McGilligan, V. E., Mc Allister, R., Matchett, K., Martin, C., Murray, EK., Lapsley, C., Rai, T. S. & Bjourson, AJ., 17 Jan 2022, Translational Autoimmunity: Treatment of Autoimmune Diseases. Rizaei, N. (ed.). 1st ed. Elsevier, Vol. 2. p. 295-318 24 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Citation (Scopus) -
2021
Deep Learning in Systems Medicine
Wang, H. . HY., Pujos-Guillot, E., Comte, B., Luis de Miranda, J., Vojtech Spiwok, Chorbev, I., Castiglione, F., Tieri, P., Watterson, S., Mc Allister, R., De Melo Malaquias, T., Zanin, M., Rai, T. S. & Zheng, H., 1 Mar 2021, In: Briefings in Bioinformatics. 22, 2, p. 1543-1559 17 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile22 Citations (Scopus)159 Downloads (Pure) -
Role of Senescence and Aging in SARS-CoV-2 Infection and COVID-19 Disease
Lynch, S. M., Guo, G., Gibson, D. S., Bjourson, A. J. & Rai, T. S., 30 Nov 2021, (Published online) In: Cells. 10, 12, 29 p., 3367.Research output: Contribution to journal › Review article › peer-review
Open AccessFile33 Citations (Scopus)65 Downloads (Pure) -
The Interdependency and Co-Regulation of the Vitamin D and Cholesterol Metabolism
Warren, T., McAllister, R., Morgan, A., Rai, T. S., McGilligan, V., Ennis, M., Page, C., Kelly, C., Peace, A., Corfe, B., Mc Auley, M. & Watterson, S., 6 Aug 2021, In: Cells. 10, 8, p. 1-18 18 p., e2007.Research output: Contribution to journal › Review article › peer-review
Open AccessFile19 Citations (Scopus)99 Downloads (Pure) -
The role of senescence in the pathogenesis of atrial fibrillation: A target process for health improvement and drug development
Guo, G., Watterson, S., Zhang, S-D., Bjourson, A., McGilligan, V., Peace, A. & Rai, T. S., 1 Aug 2021, In: Ageing research reviews. 69, p. 1-12 12 p., 101363.Research output: Contribution to journal › Review article › peer-review
Open AccessFile10 Citations (Scopus)111 Downloads (Pure) -
2019
The histone chaperone hira promotes the induction of host innate immune defences in response to HSV-1 infection
McFarlane, S., Orr, A., Roberts, A. P. E., Conn, K. L., Iliev, V., Loney, C., Filipe, A. D. S., Smollett, K., Gu, Q., Robertson, N., Adams, P. D., Rai, T. S. & Boutell, C., 1 Mar 2019, In: PLoS Pathogens. 15, 3, e1007667.Research output: Contribution to journal › Article › peer-review
35 Citations (Scopus) -
2017
Cellular senescence in osteoarthritis pathology
McCulloch, K., Litherland, G. J. & Rai, T. S., 1 Apr 2017, In: Aging Cell. 16, 2, p. 210-218 9 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile226 Citations (Scopus)91 Downloads (Pure) -
Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity
Rai, T. S., Glass, M., Cole, J. J., Rather, M. I., Marsden, M., Neilson, M., Brock, C., Humphreys, I. R., Everett, R. D. & Adams, P. D., 16 Nov 2017, In: Nucleic Acids Research. 45, 20, p. 11673-11683 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)51 Downloads (Pure) -
Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor Function
van Tuyn, J., Jaber-Hijazi, F., MacKenzie, D., Cole, J. J., Mann, E., Pawlikowski, J. S., Rai, T. S., Nelson, D. M., McBryan, T., Ivanov, A., Blyth, K., Wu, H., Milling, S. & Adams, P. D., 1 Oct 2017, In: Journal of Investigative Dermatology. 137, 10, p. 2197-2207 11 p.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus) -
2016
ChIP-Sequencing to Map the Epigenome of Senescent Cells Using Benzonase Endonuclease
Rai, T. S. & Adams, P. D., 1 Jan 2016, Enzymes of Epigenetics, Part B. Academic Press, Vol. 574. p. 355-364 10 p. (Methods in Enzymology; vol. 574).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
4 Citations (Scopus) -
Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability
Nelson, D. M., Jaber-Hijazi, F., Cole, J. J., Robertson, N. A., Pawlikowski, J. S., Norris, K. T., Criscione, S. W., Pchelintsev, N. A., Piscitello, D., Stong, N., Rai, T. S., McBryan, T., Otte, G. L., Nixon, C., Clark, W., Riethman, H., Wu, H., Schotta, G., Garcia, B. A., Neretti, N., & 3 others, 25 Jul 2016, In: Genome Biology. 17, 1, 20 p., 158.Research output: Contribution to journal › Article › peer-review
Open AccessFile55 Citations (Scopus)36 Downloads (Pure) -
Mll1 is essential for the senescenceassociated secretory phenotype
Capell, B. C., Drake, A. M., Zhu, J., Shah, P. P., Dou, Z., Dorsey, J., Simola, D. F., Donahue, G., Sammons, M., Rai, T. S., Natale, C., Ridky, T. W., Adams, P. D. & Berger, S. L., 1 Feb 2016, In: Genes and Development. 30, 3, p. 321-336 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile113 Citations (Scopus)34 Downloads (Pure) -
2015
Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex
Ricketts, M. D., Frederick, B., Hoff, H., Tang, Y., Schultz, D. C., Rai, T. S., Vizioli, M. G., Adams, P. D. & Marmorstein, R., 10 Jul 2015, In: Nature Communications. 6, p. 1-11 11 p., 7711.Research output: Contribution to journal › Article › peer-review
Open Access92 Citations (Scopus) -
2014
HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia
Rai, T. S., Cole, J. J., Nelson, D. M., Dikovskaya, D., Faller, W. J., Vizioli, M. G., Hewitt, R. N., Anannya, O., McBryan, T., Manoharan, I., Van Tuyn, J., Morrice, N., Pchelintsev, N. A., Ivanov, A., Brock, C., Drotar, M. E., Nixon, C., Clark, W., Sansom, O. J., Anderson, K. I., & 3 others, 15 Dec 2014, In: Genes and Development. 28, 24, p. 2712-2725 14 p.Research output: Contribution to journal › Article › peer-review
107 Citations (Scopus) -
2013
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
Shah, P. P., Donahue, G., Otte, G. L., Capell, B. C., Nelson, D. M., Cao, K., Aggarwala, V., Cruickshanks, H. A., Rai, T. S., McBryan, T., Gregory, B. D., Adams, P. D. & Berger, S. L., 15 Aug 2013, In: Genes and Development. 27, 16, p. 1787-1799 13 p.Research output: Contribution to journal › Article › peer-review
395 Citations (Scopus) -
Lysosome-mediated processing of chromatin in senescence
Ivanov, A., Pawlikowski, J., Manoharan, I., van Tuyn, J., Nelson, D. M., Rai, T. S., Shah, P. P., Hewitt, G., Korolchuk, V. I., Passos, J. F., Wu, H., Berger, S. L. & Adams, P. D., 1 Jul 2013, In: Journal of Cell Biology. 202, 1, p. 129—143Research output: Contribution to journal › Article › peer-review
379 Citations (Scopus) -
P53 status determines the role of autophagy in pancreatic tumour development
Rosenfeldt, M. T., O'Prey, J., Morton, J. P., Nixon, C., Mackay, G., Mrowinska, A., Au, A., Rai, T. S., Zheng, L., Ridgway, R., Adams, P. D., Anderson, K. I., Gottlieb, E., Sansom, O. J. & Ryan, K. M., 12 Dec 2013, In: Nature. 504, 7479, p. 296-300 5 p.Research output: Contribution to journal › Article › peer-review
569 Citations (Scopus) -
Placing the HIRA Histone Chaperone Complex in the Chromatin Landscape
Pchelintsev, N. A., McBryan, T., Rai, T. S., VanTuyn, J., Ray-Gallet, D., Almouzni, G. & Adams, P. D., 25 Apr 2013, In: Cell Reports. 3, 4, p. 1012-1019 8 p.Research output: Contribution to journal › Article › peer-review
102 Citations (Scopus) -
Senescent Cells Harbour Features of the Cancer Epigenome
Cruickshanks, H. A., McBryan, T., Nelson, D. M., Vanderkraats, N. D., Shah, P. P., Van Tuyn, J., Singh Rai, T., Brock, C., Donahue, G., Dunican, D. S., Drotar, M. E., Meehan, R. R., Edwards, J. R., Berger, S. L. & Adams, P. D., 1 Dec 2013, In: Nature Cell Biology. 15, 12, p. 1495-1506 12 p.Research output: Contribution to journal › Article › peer-review
260 Citations (Scopus) -
Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression
Patel, R., Gao, M., Ahmad, I., Fleming, J., Singh, L. B., Rai, T. S., McKie, A. B., Seywright, M., Barnetson, R. J., Edwards, J., Sansom, O. J. & Leung, H. Y., 1 Mar 2013, In: Journal of Clinical Investigation. 123, 3, p. 1157-1175 19 p.Research output: Contribution to journal › Article › peer-review
74 Citations (Scopus) -
2012
Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex
Tang, Y., Puri, A., Ricketts, M. D., Rai, T. S., Hoffmann, J., Hoi, E., Adams, P. D., Schultz, D. C. & Marmorstein, R., 27 Mar 2012, In: Biochemistry. 51, 12, p. 2366-2377 12 p.Research output: Contribution to journal › Article › peer-review
25 Citations (Scopus) -
Lessons from senescence: Chromatin maintenance in non-proliferating cells
Rai, T. S. & Adams, P. D., 1 Mar 2012, In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1819, 3-4, p. 322-331 10 p.Research output: Contribution to journal › Article › peer-review
51 Citations (Scopus) -
2011
Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a Histone H3.3 chaperone complex
Rai, T. S., Puri, A., McBryan, T., Hoffman, J., Tang, Y., Pchelintsev, N. A., van Tuyn, J., Marmorstein, R., Schultz, D. C. & Adams, P. D., 1 Oct 2011, In: Molecular and Cellular Biology. 31, 19, p. 4107-4118 12 p.Research output: Contribution to journal › Article › peer-review
72 Citations (Scopus) -
2010
Decreased myocardial expression of dystrophin and titin mRNA and protein in dilated cardiomyopathy: Possibly an adverse effect of TNF-α
Ahmad, S., Rai, T. S., Khullar, M., Bahl, A., Saikia, U. N., Thungapathra, M., Kumar, R. M., Mahajan, R. & Talwar, K. K., 1 Jul 2010, In: Journal of Clinical Immunology. 30, 4, p. 520-530 11 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
2009
ACE variants interact with the RAS pathway to confer risk and protection against type 2 diabetic nephropathy
Ahluwalia, T. S., Ahuja, M., Rai, T. S., Kohli, H. S., Bhansali, A., Sud, K. & Khullar, M., 1 Mar 2009, In: DNA and Cell Biology. 28, 3, p. 141-150 10 p.Research output: Contribution to journal › Article › peer-review
59 Citations (Scopus) -
A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia
Dhandapany, P. S., Sadayappan, S., Xue, Y., Powell, G. T., Rani, D. S., Nallari, P., Rai, T. S., Khullar, M., Soares, P., Bahl, A., Tharkan, J. M., Vaideeswar, P., Rathinavel, A., Narasimhan, C., Ayapati, D. R., Ayub, Q., Mehdi, S. Q., Oppenheimer, S., Richards, M. B., Price, A. L., & 5 others, 1 Feb 2009, In: Nature Genetics. 41, 2, p. 187-191 5 p.Research output: Contribution to journal › Article › peer-review
236 Citations (Scopus) -
Circulating proinflammatory cytokines and N-terminal pro-brain natriuretic peptide significantly decrease with recovery of left ventricular function in patients with dilated cardiomyopathy
Ahmad, S., Otaal, P. S., Rai, T. S., Bahl, A., Saikia, U. N., Manoj, R. K., Thungapathra, M., Talwar, K. K. & Khullar, M., 1 Jan 2009, In: Molecular and Cellular Biochemistry. 324, 1-2, p. 139-145 7 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians
Ahluwalia, T. S., Khullar, M., Ahuja, M., Kohli, H. S., Bhansali, A., Mohan, V., Venkatesan, R., Rai, T. S., Sud, K. & Singal, P. K., 9 Apr 2009, In: PLoS ONE. 4, 4, e5168.Research output: Contribution to journal › Article › peer-review
62 Citations (Scopus) -
Genetic and clinical profile of Indian patients of idiopathic restrictive cardiomyopathy with and without hypertrophy
Rai, T. S., Ahmad, S., Ahluwalia, T. S., Ahuja, M., Bahl, A., Saikia, U. N., Singh, B., Talwar, K. K. & Khullar, M., 18 May 2009, In: Molecular and Cellular Biochemistry. 331, 1-2, p. 187-192 6 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
Genotype phenotype correlations of cardiac beta-myosin heavy chain mutations in Indian patients with hypertrophic and dilated cardiomyopathy
Rai, T. S., Ahmad, S., Bahl, A., Ahuja, M., Ahluwalia, T. S., Singh, B., Talwar, K. K. & Khullar, M., 1 Jan 2009, In: Molecular and Cellular Biochemistry. 321, 1-2, p. 189-196 8 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
2008
ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy
Rai, T. S., Dhandapany, P. S., Ahluwalia, T. S., Bhardwaj, M., Bahl, A., Talwar, K. K., Nair, K., Rathinavel, A. & Khullar, M., 1 Apr 2008, In: Molecular and Cellular Biochemistry. 311, 1-2, p. 67-72 6 p.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus) -
Endothelial nitric oxide synthase gene haplotypes and diabetic nephropathy among Asian Indians
Ahluwalia, T. S., Ahuja, M., Rai, T. S., Kohli, H. S., Sud, K., Bhansali, A. & Khullar, M., 1 Jul 2008, In: Molecular and Cellular Biochemistry. 314, 1-2, p. 9-17 9 p.Research output: Contribution to journal › Article › peer-review
68 Citations (Scopus) -
Synergistic effect between apolipoprotein E and apolipoprotein A1 gene polymorphisms in the risk for coronary artery disease
Rai, T. S., Khullar, M., Sehrawat, B. S., Ahuja, M., Sharma, P. K., Vijayvergiya, R. & Grover, A., 1 Jun 2008, In: Molecular and Cellular Biochemistry. 313, 1-2, p. 139-146 8 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus)