An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures

Divakar Dahiya, Poonam Singh - Nee Nigam

Research output: Contribution to journalReview articlepeer-review

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Abstract: This article includes a general overview of the published research on a topic relevant to
biomedical sciences research, pharma-industries and healthcare sector. We have presented a concise
information on three enzymes. These biomolecules have been investigated for their biocatalytic
activities beneficial in the detection of drugs and their metabolites present in micro-quantities in
samples of blood, urine, and other body fluids, such as salicylate hydroxylase, and dihydrofolate
reductase. Some enzymes are useful in biotransformation of compounds to convert them in an
optically active form, such as lipase. The information presented in this article has been collected
from the published studies on their catalytic function, and biosynthesis using selected
microorganisms. Several diagnostic assays are currently using enzymes as effective biocatalysts to
perform the detection-test. For the marketing and consumer’s convenience, pharmaceutical
companies have designed biosensors and diagnostic kits by incorporating specific enzymes for rapid
tests required in pathology, as well as for the quantification of certain metabolites and chemicals in
pathology samples in a shorter time. For such purpose use of enzymes synthesized by selected
specific microorganisms.
Original languageEnglish
Pages (from-to)124-137
Number of pages14
JournalAIMS Microbiology
Issue number2
Publication statusPublished - 27 Apr 2021


  • Salicylate Hydroxylase
  • Dihydrofolate reductase
  • Lipase
  • Aspirin
  • Methotrexate


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