Comparative in vitro evaluation of glimepiride containing nanosuspension drug delivery system developed by different techniques

Sujit Bose, Pooja Sharma, Vijay Mishra, Swati Patial, Gaurav K. Saraogi, Murtaza M. Tambuwala, Kamal Dua

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1 Citation (Scopus)

Abstract

The present study was aimed to develop the Glimepiride (GLM) loaded nanosuspension by different methods for increasing the solubility of GLM. Twelve formulations were prepared by combination method (FG), which included antisolvent precipitation method followed by sonication (Method 1) selecting drug and polymer in ratio of 1:10, 1:20 and 1:30. Further 6 formulations were prepared by nanoprecipitation method (Fg) (Method 2) selecting drug and polymer in ratio of 1:10, 1:20 by using different polymers like polyvinyl pyrolidone (PVP K30), and poly(ethylene glycol) (PEG) such as PEG6000 and PEG400. The GLM nanosuspensions prepared by different techniques were evaluated by optical microscopy, percent entrapment efficiency (%EE), particle size analysis, zeta potential, transmission electron microscopy (TEM) and in vitro dissolution. FG1 formulation was found to be better formulation showing 82.04% EE, 129-180 nm particle size range, 30.16 mV zeta potential, 0.253 polydispersity index (PDI) and 86.76% drug release as compared to Fgii formulation having %EE, average particle size, zeta potential, PDI value and drug release as 80.03%, 72-383 nm, -22.19 mV, 0.358 and 74.77%, respectively. On the basis of results obtained from different studies, it can be concluded that GLM nanosuspension prepared by combination technique (FG) shows good solubility and dissolution than those prepared by nanoprecipitation technique (Fg), hence the combination technique is found to be a preferred technique to prepare GLM nanosuspension over nanoprecipitation technique.
Original languageEnglish
Article number129927
Number of pages32
JournalJournal of Molecular Structure
Volume1231
Early online date11 Jan 2021
DOIs
Publication statusPublished - 5 May 2021

Keywords

  • Antidiabetic
  • Diabetes mellitus
  • Drug delivery
  • Glimepiride
  • Nanosuspension
  • Polymers

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