Exercise and Cardioprotection in Coronary Artery Disease: A Pilot Quasi-Experimental Study

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Sirtuin-1 (SIRT-1) is a protein that may orchestrate the cardioprotective effect of exercise by controlling cellular processes. This pilot study assessed the feasibility of performing a quasi-experimental study in this area. Post-acute myocardial infarction patients were recruited across four hospital sites in the United Kingdom. Participants were offered one weekly exercise session at phase-III and phase-IV cardiac rehabilitation (CR). Measurements were obtained pre-phase-III CR (week-1), post-phase-III CR (week-8), and post-phase-IV CR (week-22). Twenty-eight patients were recruited (79% male, 100% white, 60.2 ± 10.5 years old). Recruitment rate was not fulfilled (< 70% eligible patients recruited; 0.9 participants recruited per week over 30 weeks). Success criteria for drop-out rate, adherence rate, and collection of SIRT-1 measures were satisfied. A large increase in SIRT-1 (0.14 ± 0.03, d ≥ 0.8) was seen after phase-III and phase-IV CR. Collectively, a quasi-experimental study is feasible with a revised recruitment strategy.
Original languageEnglish
JournalJournal of Aging and Physical Activity
Publication statusAccepted/In press - 14 May 2021

Bibliographical note

Managing org unit is Health Sciences, so maximum embargo is 12 months.


  • cardiac rehabilitation
  • Inflammation
  • Endothelial function
  • Molecular mechanisms
  • Feasibility


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