An intelligent cardiovascular disease (CVD) diagnosis system using hemodynamic parameters (HDPs) derived from sphygmogram (SPG) signal is presented to support the emerging patient-centric healthcare models. To replicate clinical approach of diagnosis through a staged decision process, the Bayesian inference nets (BIN) are adapted. New approaches to construct a hierarchical multistage BIN using defined function formulas and a method employing fuzzy logic (FL) technology to quantify inference nodes with dynamic values of statistical parameters are proposed. The suggested methodology is validated by constructing hierarchical Bayesian fuzzy inference nets (HBFIN) to diagnose various heart pathologies from the deduced HDPs. The preliminary diagnostic results show that the proposed methodology has salient validity and effectiveness in the diagnosis of cardiovascular disease.