Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

J. Deelen; M. Beekman; H.-W. Uh; L. Broer; K.L. Ayers; Q. Tan; Y. Kamatani; A.M. Bennet; R. Tamm; S. Trompet; D.F. Guobjartsson; F. Flachsbart; G. Rose; A. Viktorin; K. Fischer; M. Nygaard; H.J. Cordell; P. Crocco; E.B. Van Den Akker; S. Böhringer; Q. Helmer; C.P. Nelson; G.I. Saunders; M. Alver; K. Andersen-Ranberg; M.E. Breen; R. van Der Breggen; A. Caliebe; M. Capri; E. Cevenini; J.C. Collerton; S. Dato; K. Davies; I. Ford; J. Gampe; P. Garagnani; E.J.C. de Geus; J. Harrow; D. Van Heemst; B.T. Heijmans; F.-A. Heinsen; J.-J. Hottenga; A. Hofman; B. Jeune; P.V. Jonsson; M. Lathrop; D. Lechner; C. Martin-Ruiz; S.E. Mcnerlan; E. Mihailov; A. Montesanto; S.P. Mooijaart; A. Murphy; E.A. Nohr; L. Paternoster; I. Postmus; F. Rivadeneira; O.A. Ross; S. Salvioli; N. Sattar; S. Schreiber; H. Stefánsson; D.J. Stott; H. Tiemeier; A.G. Uitterlinden; R.G.J. Westendorp; G. Willemsen; N.J. Samani; P. Galan; T.I.A. Sørensen; D.I. Boomsma; J. Wouter Jukema; I.M. Rea; G. Passarino; A.J.M. de Craen; K. Christensen; A. Nebel; K. Stefánsson; A. Metspalu; P. Magnusson; H. Blanché; L. Christiansen; T.B.L. Kirkwood; C.M. Van Duijn; C. Franceschi; J.J. Houwing-Duistermaat; P.E. Slagboom

doi:10.1093/hmg/ddu139

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

J. Deelen, M. Beekman, H.-W. Uh, L. Broer, K.L. Ayers, Q. Tan, Y. Kamatani, A.M. Bennet, R. Tamm, S. Trompet, D.F. Guobjartsson, F. Flachsbart, G. Rose, A. Viktorin, K. Fischer, M. Nygaard, H.J. Cordell, P. Crocco, E.B. Van Den Akker, S. BöhringerQ. Helmer, C.P. Nelson, G.I. Saunders, M. Alver, K. Andersen-Ranberg, M.E. Breen, R. van Der Breggen, A. Caliebe, M. Capri, E. Cevenini, J.C. Collerton, S. Dato, K. Davies, I. Ford, J. Gampe, P. Garagnani, E.J.C. de Geus, J. Harrow, D. Van Heemst, B.T. Heijmans, F.-A. Heinsen, J.-J. Hottenga, A. Hofman, B. Jeune, P.V. Jonsson, M. Lathrop, D. Lechner, C. Martin-Ruiz, S.E. Mcnerlan, E. Mihailov, A. Montesanto, S.P. Mooijaart, A. Murphy, E.A. Nohr, L. Paternoster, I. Postmus, F. Rivadeneira, O.A. Ross, S. Salvioli, N. Sattar, S. Schreiber, H. Stefánsson, D.J. Stott, H. Tiemeier, A.G. Uitterlinden, R.G.J. Westendorp, G. Willemsen, N.J. Samani, P. Galan, T.I.A. Sørensen, D.I. Boomsma, J. Wouter Jukema, I.M. Rea, G. Passarino, A.J.M. de Craen, K. Christensen, A. Nebel, K. Stefánsson, A. Metspalu, P. Magnusson, H. Blanché, L. Christiansen, T.B.L. Kirkwood, C.M. Van Duijn, C. Franceschi, J.J. Houwing-Duistermaat, P.E. Slagboom

Research output: Contribution to journal › Article › peer-review

154 Citations (Scopus)

Original language	English
Pages (from-to)	4420-4432
Journal	Human Molecular Genetics
Volume	23
Issue number	16
DOIs	https://doi.org/10.1093/hmg/ddu139
Publication status	Published - 31 Mar 2014

Keywords

EMTREE medical terms: aged
allele
article
blood pressure
cardiovascular disease
cardiovascular risk
cerebrovascular accident
chromosome 19q
chromosome 5q
controlled study
coronary artery disease
disease predisposition
Europe
female
follow up
gene linkage disequilibrium
gene locus
gene mapping
gene replication
genetic association
heritability
human
hypotension
lifespan
longevity
major clinical study
male
phenotype
pleiotropy
priority journal
prospective study
single nucleotide polymorphism
survival
very elderly
aging
Article
cardiovascular mortality
European
genetic risk
genetic variability

Access to Document

10.1093/hmg/ddu139

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904741764&doi=10.1093%2fhmg%2fddu139&partnerID=40&md5=32756a763dd5e6325c0dc7d55d5428e7

Cite this

Deelen, J., Beekman, M., Uh, H-W., Broer, L., Ayers, K. L., Tan, Q., Kamatani, Y., Bennet, A. M., Tamm, R., Trompet, S., Guobjartsson, D. F., Flachsbart, F., Rose, G., Viktorin, A., Fischer, K., Nygaard, M., Cordell, H. J., Crocco, P., Van Den Akker, E. B., ... Slagboom, P. E. (2014). Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Human Molecular Genetics, 23(16), 4420-4432. https://doi.org/10.1093/hmg/ddu139

Deelen, J. ; Beekman, M. ; Uh, H.-W. ; Broer, L. ; Ayers, K.L. ; Tan, Q. ; Kamatani, Y. ; Bennet, A.M. ; Tamm, R. ; Trompet, S. ; Guobjartsson, D.F. ; Flachsbart, F. ; Rose, G. ; Viktorin, A. ; Fischer, K. ; Nygaard, M. ; Cordell, H.J. ; Crocco, P. ; Van Den Akker, E.B. ; Böhringer, S. ; Helmer, Q. ; Nelson, C.P. ; Saunders, G.I. ; Alver, M. ; Andersen-Ranberg, K. ; Breen, M.E. ; van Der Breggen, R. ; Caliebe, A. ; Capri, M. ; Cevenini, E. ; Collerton, J.C. ; Dato, S. ; Davies, K. ; Ford, I. ; Gampe, J. ; Garagnani, P. ; de Geus, E.J.C. ; Harrow, J. ; Van Heemst, D. ; Heijmans, B.T. ; Heinsen, F.-A. ; Hottenga, J.-J. ; Hofman, A. ; Jeune, B. ; Jonsson, P.V. ; Lathrop, M. ; Lechner, D. ; Martin-Ruiz, C. ; Mcnerlan, S.E. ; Mihailov, E. ; Montesanto, A. ; Mooijaart, S.P. ; Murphy, A. ; Nohr, E.A. ; Paternoster, L. ; Postmus, I. ; Rivadeneira, F. ; Ross, O.A. ; Salvioli, S. ; Sattar, N. ; Schreiber, S. ; Stefánsson, H. ; Stott, D.J. ; Tiemeier, H. ; Uitterlinden, A.G. ; Westendorp, R.G.J. ; Willemsen, G. ; Samani, N.J. ; Galan, P. ; Sørensen, T.I.A. ; Boomsma, D.I. ; Wouter Jukema, J. ; Rea, I.M. ; Passarino, G. ; de Craen, A.J.M. ; Christensen, K. ; Nebel, A. ; Stefánsson, K. ; Metspalu, A. ; Magnusson, P. ; Blanché, H. ; Christiansen, L. ; Kirkwood, T.B.L. ; Van Duijn, C.M. ; Franceschi, C. ; Houwing-Duistermaat, J.J. ; Slagboom, P.E. / Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. In: Human Molecular Genetics. 2014 ; Vol. 23, No. 16. pp. 4420-4432.

@article{01156e0dba98481b80b89537113403ab,

title = "Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age",

keywords = "EMTREE medical terms: aged, allele, article, blood pressure, cardiovascular disease, cardiovascular risk, cerebrovascular accident, chromosome 19q, chromosome 5q, controlled study, coronary artery disease, disease predisposition, Europe, female, follow up, gene linkage disequilibrium, gene locus, gene mapping, gene replication, genetic association, heritability, human, hypotension, lifespan, longevity, major clinical study, male, phenotype, pleiotropy, priority journal, prospective study, single nucleotide polymorphism, survival, very elderly, aging, Article, cardiovascular mortality, European, genetic risk, genetic variability",

author = "J. Deelen and M. Beekman and H.-W. Uh and L. Broer and K.L. Ayers and Q. Tan and Y. Kamatani and A.M. Bennet and R. Tamm and S. Trompet and D.F. Guobjartsson and F. Flachsbart and G. Rose and A. Viktorin and K. Fischer and M. Nygaard and H.J. Cordell and P. Crocco and {Van Den Akker}, E.B. and S. B{\"o}hringer and Q. Helmer and C.P. Nelson and G.I. Saunders and M. Alver and K. Andersen-Ranberg and M.E. Breen and {van Der Breggen}, R. and A. Caliebe and M. Capri and E. Cevenini and J.C. Collerton and S. Dato and K. Davies and I. Ford and J. Gampe and P. Garagnani and {de Geus}, E.J.C. and J. Harrow and {Van Heemst}, D. and B.T. Heijmans and F.-A. Heinsen and J.-J. Hottenga and A. Hofman and B. Jeune and P.V. Jonsson and M. Lathrop and D. Lechner and C. Martin-Ruiz and S.E. Mcnerlan and E. Mihailov and A. Montesanto and S.P. Mooijaart and A. Murphy and E.A. Nohr and L. Paternoster and I. Postmus and F. Rivadeneira and O.A. Ross and S. Salvioli and N. Sattar and S. Schreiber and H. Stef{\'a}nsson and D.J. Stott and H. Tiemeier and A.G. Uitterlinden and R.G.J. Westendorp and G. Willemsen and N.J. Samani and P. Galan and T.I.A. S{\o}rensen and D.I. Boomsma and {Wouter Jukema}, J. and I.M. Rea and G. Passarino and {de Craen}, A.J.M. and K. Christensen and A. Nebel and K. Stef{\'a}nsson and A. Metspalu and P. Magnusson and H. Blanch{\'e} and L. Christiansen and T.B.L. Kirkwood and {Van Duijn}, C.M. and C. Franceschi and J.J. Houwing-Duistermaat and P.E. Slagboom",

note = "cited By 56",

year = "2014",

month = mar,

day = "31",

doi = "10.1093/hmg/ddu139",

language = "English",

volume = "23",

pages = "4420--4432",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

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Deelen, J, Beekman, M, Uh, H-W, Broer, L, Ayers, KL, Tan, Q, Kamatani, Y, Bennet, AM, Tamm, R, Trompet, S, Guobjartsson, DF, Flachsbart, F, Rose, G, Viktorin, A, Fischer, K, Nygaard, M, Cordell, HJ, Crocco, P, Van Den Akker, EB, Böhringer, S, Helmer, Q, Nelson, CP, Saunders, GI, Alver, M, Andersen-Ranberg, K, Breen, ME, van Der Breggen, R, Caliebe, A, Capri, M, Cevenini, E, Collerton, JC, Dato, S, Davies, K, Ford, I, Gampe, J, Garagnani, P, de Geus, EJC, Harrow, J, Van Heemst, D, Heijmans, BT, Heinsen, F-A, Hottenga, J-J, Hofman, A, Jeune, B, Jonsson, PV, Lathrop, M, Lechner, D, Martin-Ruiz, C, Mcnerlan, SE, Mihailov, E, Montesanto, A, Mooijaart, SP, Murphy, A, Nohr, EA, Paternoster, L, Postmus, I, Rivadeneira, F, Ross, OA, Salvioli, S, Sattar, N, Schreiber, S, Stefánsson, H, Stott, DJ, Tiemeier, H, Uitterlinden, AG, Westendorp, RGJ, Willemsen, G, Samani, NJ, Galan, P, Sørensen, TIA, Boomsma, DI, Wouter Jukema, J, Rea, IM, Passarino, G, de Craen, AJM, Christensen, K, Nebel, A, Stefánsson, K, Metspalu, A, Magnusson, P, Blanché, H, Christiansen, L, Kirkwood, TBL, Van Duijn, CM, Franceschi, C, Houwing-Duistermaat, JJ & Slagboom, PE 2014, 'Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age', Human Molecular Genetics, vol. 23, no. 16, pp. 4420-4432. https://doi.org/10.1093/hmg/ddu139

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. / Deelen, J.; Beekman, M.; Uh, H.-W.; Broer, L.; Ayers, K.L.; Tan, Q.; Kamatani, Y.; Bennet, A.M.; Tamm, R.; Trompet, S.; Guobjartsson, D.F.; Flachsbart, F.; Rose, G.; Viktorin, A.; Fischer, K.; Nygaard, M.; Cordell, H.J.; Crocco, P.; Van Den Akker, E.B.; Böhringer, S.; Helmer, Q.; Nelson, C.P.; Saunders, G.I.; Alver, M.; Andersen-Ranberg, K.; Breen, M.E.; van Der Breggen, R.; Caliebe, A.; Capri, M.; Cevenini, E.; Collerton, J.C.; Dato, S.; Davies, K.; Ford, I.; Gampe, J.; Garagnani, P.; de Geus, E.J.C.; Harrow, J.; Van Heemst, D.; Heijmans, B.T.; Heinsen, F.-A.; Hottenga, J.-J.; Hofman, A.; Jeune, B.; Jonsson, P.V.; Lathrop, M.; Lechner, D.; Martin-Ruiz, C.; Mcnerlan, S.E.; Mihailov, E.; Montesanto, A.; Mooijaart, S.P.; Murphy, A.; Nohr, E.A.; Paternoster, L.; Postmus, I.; Rivadeneira, F.; Ross, O.A.; Salvioli, S.; Sattar, N.; Schreiber, S.; Stefánsson, H.; Stott, D.J.; Tiemeier, H.; Uitterlinden, A.G.; Westendorp, R.G.J.; Willemsen, G.; Samani, N.J.; Galan, P.; Sørensen, T.I.A.; Boomsma, D.I.; Wouter Jukema, J.; Rea, I.M.; Passarino, G.; de Craen, A.J.M.; Christensen, K.; Nebel, A.; Stefánsson, K.; Metspalu, A.; Magnusson, P.; Blanché, H.; Christiansen, L.; Kirkwood, T.B.L.; Van Duijn, C.M.; Franceschi, C.; Houwing-Duistermaat, J.J.; Slagboom, P.E.

In: Human Molecular Genetics, Vol. 23, No. 16, 31.03.2014, p. 4420-4432.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

AU - Deelen, J.

AU - Beekman, M.

AU - Uh, H.-W.

AU - Broer, L.

AU - Ayers, K.L.

AU - Tan, Q.

AU - Kamatani, Y.

AU - Bennet, A.M.

AU - Tamm, R.

AU - Trompet, S.

AU - Guobjartsson, D.F.

AU - Flachsbart, F.

AU - Rose, G.

AU - Viktorin, A.

AU - Fischer, K.

AU - Nygaard, M.

AU - Cordell, H.J.

AU - Crocco, P.

AU - Van Den Akker, E.B.

AU - Böhringer, S.

AU - Helmer, Q.

AU - Nelson, C.P.

AU - Saunders, G.I.

AU - Alver, M.

AU - Andersen-Ranberg, K.

AU - Breen, M.E.

AU - van Der Breggen, R.

AU - Caliebe, A.

AU - Capri, M.

AU - Cevenini, E.

AU - Collerton, J.C.

AU - Dato, S.

AU - Davies, K.

AU - Ford, I.

AU - Gampe, J.

AU - Garagnani, P.

AU - de Geus, E.J.C.

AU - Harrow, J.

AU - Van Heemst, D.

AU - Heijmans, B.T.

AU - Heinsen, F.-A.

AU - Hottenga, J.-J.

AU - Hofman, A.

AU - Jeune, B.

AU - Jonsson, P.V.

AU - Lathrop, M.

AU - Lechner, D.

AU - Martin-Ruiz, C.

AU - Mcnerlan, S.E.

AU - Mihailov, E.

AU - Montesanto, A.

AU - Mooijaart, S.P.

AU - Murphy, A.

AU - Nohr, E.A.

AU - Paternoster, L.

AU - Postmus, I.

AU - Rivadeneira, F.

AU - Ross, O.A.

AU - Salvioli, S.

AU - Sattar, N.

AU - Schreiber, S.

AU - Stefánsson, H.

AU - Stott, D.J.

AU - Tiemeier, H.

AU - Uitterlinden, A.G.

AU - Westendorp, R.G.J.

AU - Willemsen, G.

AU - Samani, N.J.

AU - Galan, P.

AU - Sørensen, T.I.A.

AU - Boomsma, D.I.

AU - Wouter Jukema, J.

AU - Rea, I.M.

AU - Passarino, G.

AU - de Craen, A.J.M.

AU - Christensen, K.

AU - Nebel, A.

AU - Stefánsson, K.

AU - Metspalu, A.

AU - Magnusson, P.

AU - Blanché, H.

AU - Christiansen, L.

AU - Kirkwood, T.B.L.

AU - Van Duijn, C.M.

AU - Franceschi, C.

AU - Houwing-Duistermaat, J.J.

AU - Slagboom, P.E.

N1 - cited By 56

PY - 2014/3/31

Y1 - 2014/3/31

KW - EMTREE medical terms: aged

KW - allele

KW - article

KW - blood pressure

KW - cardiovascular disease

KW - cardiovascular risk

KW - cerebrovascular accident

KW - chromosome 19q

KW - chromosome 5q

KW - controlled study

KW - coronary artery disease

KW - disease predisposition

KW - Europe

KW - female

KW - follow up

KW - gene linkage disequilibrium

KW - gene locus

KW - gene mapping

KW - gene replication

KW - genetic association

KW - heritability

KW - human

KW - hypotension

KW - lifespan

KW - longevity

KW - major clinical study

KW - male

KW - phenotype

KW - pleiotropy

KW - priority journal

KW - prospective study

KW - single nucleotide polymorphism

KW - survival

KW - very elderly

KW - aging

KW - Article

KW - cardiovascular mortality

KW - European

KW - genetic risk

KW - genetic variability

U2 - 10.1093/hmg/ddu139

DO - 10.1093/hmg/ddu139

M3 - Article

VL - 23

SP - 4420

EP - 4432

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 16

ER -