BACKGROUND: In the present study we assessed the impact of neuropeptide Y receptor (NPYR) modulators, neuropeptide Y (NPY) and pancreatic polypeptide (PP), on islet function and beta-cell survival.METHODS: The effects of NPY and PP on beta-cell function were examined in BRIN BD11 and 1.1B4 beta-cells, as well as isolated mouse islets. Involvement of both peptides in pancreatic islet adaptations to streptozotocin and hydrocortisone, as well as effects on beta-cell proliferation and apoptosis was also evaluated.RESULTS: Neither NPY nor PP affected in vivo glucose disposal or insulin secretion in mice. However, both peptides inhibited (p
|Journal||Biochimica et Biophysica Acta (BBA) - General Subjects|
|Early online date||7 Jan 2017|
|Publication status||E-pub ahead of print - 7 Jan 2017|
Bibliographical noteCompliant in UIR; evidence uploaded to 'Other files'
- Neuropeptide Y
- Pancreatic polypeptide
- Insulin secretion