Lipopeptide Biosurfactant from Acinetobacter junii B6: A Promising Natural Surfactant for Promoting Angiogenesis

Mehrnaz Mehrabani; Mojdeh Esmaeili-Tarzi; Hamid Forootanfar; Mohammad Hadi Nematollahi; Ibrahim M Banat; Mandana Ohadi; Gholamreza Dehghannoudeh

doi:https://doi.org/10.1007/s10989-021-10160-9

Lipopeptide Biosurfactant from Acinetobacter junii B6: A Promising Natural Surfactant for Promoting Angiogenesis

Mehrnaz Mehrabani, Mojdeh Esmaeili-Tarzi, Hamid Forootanfar, Mohammad Hadi Nematollahi, Ibrahim M Banat, Mandana Ohadi, Gholamreza Dehghannoudeh

Research output: Contribution to journal › Article › peer-review

Abstract

Lipopeptide biosurfactants (LPBs) display unique properties with widespread therapeutic applications. Recently, the wound healing activity of LPBs has received more attention. However, few investigations have focused on the healing mechanisms of these compounds, particularly those that are associated with the angiogenic pathways. Therefore, the current study aimed at
investigating the efect of a natural LPB produced by Acinetobacter. junii B6 on the angiogenic potential of human umbilical vein endothelial cells (HUVECs). The proliferation, migration, and three-dimensional tube forming potential of HUVECs were examined after treatment with LPB. By using western blotting, the expression of angiogenic-related genes such as hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) were also measured. LPB demonstrated no signifcant proliferative or cytotoxic efect on HUVECs at the concentrations lower than 600 µg/mL. Moreover, LPB at a concentration of 300 µg/mL caused a signifcant increase in the rates of migration and tube formation of HUVECs. LPB also enhanced the protein expression levels of HIF-1α and VEGF in HUVECs in a dose-dependent manner. The present results suggest that LPB might be considered a potential wound healing agent by modifying some angiogenic factors.

Original language	English
Number of pages	7
Journal	International Journal of Peptide Research and Therapeutics
DOIs	https://doi.org/10.1007/s10989-021-10160-9
Publication status	Published - 23 Jan 2021

Keywords

Acinetobacter junii
Angiogenesis
Lipopeptide biosurfactant
Wound healing

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title = "Lipopeptide Biosurfactant from Acinetobacter junii B6: A Promising Natural Surfactant for Promoting Angiogenesis",

abstract = "Lipopeptide biosurfactants (LPBs) display unique properties with widespread therapeutic applications. Recently, the wound healing activity of LPBs has received more attention. However, few investigations have focused on the healing mechanisms of these compounds, particularly those that are associated with the angiogenic pathways. Therefore, the current study aimed atinvestigating the efect of a natural LPB produced by Acinetobacter. junii B6 on the angiogenic potential of human umbilical vein endothelial cells (HUVECs). The proliferation, migration, and three-dimensional tube forming potential of HUVECs were examined after treatment with LPB. By using western blotting, the expression of angiogenic-related genes such as hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) were also measured. LPB demonstrated no signifcant proliferative or cytotoxic efect on HUVECs at the concentrations lower than 600 µg/mL. Moreover, LPB at a concentration of 300 µg/mL caused a signifcant increase in the rates of migration and tube formation of HUVECs. LPB also enhanced the protein expression levels of HIF-1α and VEGF in HUVECs in a dose-dependent manner. The present results suggest that LPB might be considered a potential wound healing agent by modifying some angiogenic factors.",

keywords = "Acinetobacter junii, Angiogenesis, Lipopeptide biosurfactant, Wound healing",

author = "Mehrnaz Mehrabani and Mojdeh Esmaeili-Tarzi and Hamid Forootanfar and Nematollahi, {Mohammad Hadi} and Banat, {Ibrahim M} and Mandana Ohadi and Gholamreza Dehghannoudeh",

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doi = "https://doi.org/10.1007/s10989-021-10160-9",

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Lipopeptide Biosurfactant from Acinetobacter junii B6: A Promising Natural Surfactant for Promoting Angiogenesis. / Mehrabani, Mehrnaz; Esmaeili-Tarzi, Mojdeh; Forootanfar, Hamid; Nematollahi, Mohammad Hadi; Banat, Ibrahim M; Ohadi, Mandana; Dehghannoudeh, Gholamreza.

In: International Journal of Peptide Research and Therapeutics, 23.01.2021.

Research output: Contribution to journal › Article › peer-review

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T1 - Lipopeptide Biosurfactant from Acinetobacter junii B6: A Promising Natural Surfactant for Promoting Angiogenesis

AU - Mehrabani, Mehrnaz

AU - Esmaeili-Tarzi, Mojdeh

AU - Forootanfar, Hamid

AU - Nematollahi, Mohammad Hadi

AU - Banat, Ibrahim M

AU - Ohadi, Mandana

AU - Dehghannoudeh, Gholamreza

PY - 2021/1/23

Y1 - 2021/1/23

N2 - Lipopeptide biosurfactants (LPBs) display unique properties with widespread therapeutic applications. Recently, the wound healing activity of LPBs has received more attention. However, few investigations have focused on the healing mechanisms of these compounds, particularly those that are associated with the angiogenic pathways. Therefore, the current study aimed atinvestigating the efect of a natural LPB produced by Acinetobacter. junii B6 on the angiogenic potential of human umbilical vein endothelial cells (HUVECs). The proliferation, migration, and three-dimensional tube forming potential of HUVECs were examined after treatment with LPB. By using western blotting, the expression of angiogenic-related genes such as hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) were also measured. LPB demonstrated no signifcant proliferative or cytotoxic efect on HUVECs at the concentrations lower than 600 µg/mL. Moreover, LPB at a concentration of 300 µg/mL caused a signifcant increase in the rates of migration and tube formation of HUVECs. LPB also enhanced the protein expression levels of HIF-1α and VEGF in HUVECs in a dose-dependent manner. The present results suggest that LPB might be considered a potential wound healing agent by modifying some angiogenic factors.

AB - Lipopeptide biosurfactants (LPBs) display unique properties with widespread therapeutic applications. Recently, the wound healing activity of LPBs has received more attention. However, few investigations have focused on the healing mechanisms of these compounds, particularly those that are associated with the angiogenic pathways. Therefore, the current study aimed atinvestigating the efect of a natural LPB produced by Acinetobacter. junii B6 on the angiogenic potential of human umbilical vein endothelial cells (HUVECs). The proliferation, migration, and three-dimensional tube forming potential of HUVECs were examined after treatment with LPB. By using western blotting, the expression of angiogenic-related genes such as hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) were also measured. LPB demonstrated no signifcant proliferative or cytotoxic efect on HUVECs at the concentrations lower than 600 µg/mL. Moreover, LPB at a concentration of 300 µg/mL caused a signifcant increase in the rates of migration and tube formation of HUVECs. LPB also enhanced the protein expression levels of HIF-1α and VEGF in HUVECs in a dose-dependent manner. The present results suggest that LPB might be considered a potential wound healing agent by modifying some angiogenic factors.

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KW - Angiogenesis

KW - Lipopeptide biosurfactant

KW - Wound healing

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DO - https://doi.org/10.1007/s10989-021-10160-9

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JO - International Journal of Peptide Research and Therapeutics

JF - International Journal of Peptide Research and Therapeutics

SN - 1573-3149

ER -

Lipopeptide Biosurfactant from Acinetobacter junii B6: A Promising Natural Surfactant for Promoting Angiogenesis

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Keywords

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