Lipopeptide Biosurfactant from Acinetobacter junii B6: A Promising Natural Surfactant for Promoting Angiogenesis

Mehrnaz Mehrabani, Mojdeh Esmaeili-Tarzi, Hamid Forootanfar, Mohammad Hadi Nematollahi, Ibrahim M Banat, Mandana Ohadi, Gholamreza Dehghannoudeh

Research output: Contribution to journalArticlepeer-review


Lipopeptide biosurfactants (LPBs) display unique properties with widespread therapeutic applications. Recently, the wound healing activity of LPBs has received more attention. However, few investigations have focused on the healing mechanisms of these compounds, particularly those that are associated with the angiogenic pathways. Therefore, the current study aimed at
investigating the efect of a natural LPB produced by Acinetobacter. junii B6 on the angiogenic potential of human umbilical vein endothelial cells (HUVECs). The proliferation, migration, and three-dimensional tube forming potential of HUVECs were examined after treatment with LPB. By using western blotting, the expression of angiogenic-related genes such as hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) were also measured. LPB demonstrated no signifcant proliferative or cytotoxic efect on HUVECs at the concentrations lower than 600 µg/mL. Moreover, LPB at a concentration of 300 µg/mL caused a signifcant increase in the rates of migration and tube formation of HUVECs. LPB also enhanced the protein expression levels of HIF-1α and VEGF in HUVECs in a dose-dependent manner. The present results suggest that LPB might be considered a potential wound healing agent by modifying some angiogenic factors.
Original languageEnglish
Number of pages7
JournalInternational Journal of Peptide Research and Therapeutics
Publication statusPublished - 23 Jan 2021

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© 2021, The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.

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  • Acinetobacter junii
  • Angiogenesis
  • Lipopeptide biosurfactant
  • Wound healing


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