Microparticle filtration using carbon nanotubes and impedance characterisation for gold microelectrodes sensor system

A. Mathur, E. M. Hamad, S. Mukhopadhyay, S. S. Roy, J. A. McLaughlin

    Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

    Abstract

    Blood-cell-free serum is required for most clinical chemistry tests. At present bend micro channel and polymeric pillars are used in polymer based microfluidic devices (such as PMMA) for the blood filtration. In this study, we have fabricated carbon nanotube (CNT) pillars on silicon from 20-50 μm in diameter with ∼10 μm spacing and integrate them inside the microfluidic channel with a view of using these for blood plasma filtration from whole blood, with passive capillary flow. Our main objective is to design a novel sensor, comprising CNT arrays, to filter/control whole blood flow, with an integrated micro patterned gold electrode which will be sealed by bonding into microfluidics structures. We have characterized the microfluidic channel by measuring the meniscus movement profiles. Also gold inter-digitated electrodes (IDEs) were fabricated on glass and immobilized with an antibody. These IDEs were used as an impedance-based biosensor using label-free antigen - antibody interaction. At a fixed frequency, the IDEs gave a linear response across the range of concentrations of secondary antibodies investigated (0 to 500 μg/mL).

    Original languageEnglish
    Title of host publicationLarge-Area Electronics from Carbon Nanotubes, Graphene, and Related Noncarbon Nanostructures
    Pages32-37
    Number of pages6
    Publication statusPublished - 2010
    Event2009 MRS Fall Meeting - Boston, MA, United States
    Duration: 30 Nov 20094 Dec 2009

    Publication series

    NameMaterials Research Society Symposium Proceedings
    Volume1205
    ISSN (Print)0272-9172

    Conference

    Conference2009 MRS Fall Meeting
    CountryUnited States
    CityBoston, MA
    Period30/11/094/12/09

    Keywords

    • Bio-sensing
    • Carbon nanotubes (CNTs)
    • Hot embossing
    • Poly methyl meth acralate (PMMA)

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