Pharmacological effects of natural Ganoderma and its extracts on neurological diseases: A comprehensive review

Chen Zhao, Chunchen Zhang, Zheng Xing, Zeeshan Ahmad, Jing Song Li, Ming Wei Chang

Research output: Contribution to journalReview articlepeer-review

27 Citations (Scopus)


Ganoderma, has been used for clinical applications for thousands of years as a highly-nutritious and significantly-effective medicinal herb. The active components and efficacy of Ganoderma are constantly being explored and supplemented every year. In recent years, more and more literature has reported the pharmacological effects of Ganoderma on anti-tumor, liver protection and immunity enhancement, especially on neuroprotection. Numerous research works on the neuroprotective effects of Ganoderma have been documented (e.g., modulation of neurogenesis, amelioration of Alzheimer's disease, therapeutic effect on epilepsy, the protective effect on neural cells in stroke injury, etc.) thus it has drawn increasing attention. However, an integrated and comprehensive review of recent research findings has not been detailed in any great depth. Therefore, the purpose of this review is to summarize and elucidate recent progress of neuroprotective effects of natural Ganoderma and its extracts.

Original languageEnglish
Pages (from-to)1160-1178
Number of pages19
JournalInternational Journal of Biological Macromolecules
Early online date18 Oct 2018
Publication statusPublished - 1 Jan 2019

Bibliographical note

No accepted version, not for REF. Ming-Wei was not employed in the UK at time of acceptance or publication.


  • Ganoderma
  • Neurological diseases
  • Traditional Chinese medicine


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