Plants derived therapeutic strategies targeting chronic respiratory diseases: Chemical and immunological perspective

Parteek Prasher, Mousmee Sharma, Meenu Mehta, Keshav R. Paudel, Saurabh Satija, Dinesh K. Chellappan, Harish Dureja, Gaurav Gupta, Murtaza M. Tambuwala, Poonam Negi, Peter R. Wich, Nicole Hansbro, Philip M. Hansbro, Kamal Dua

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
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Abstract

The apparent predicament of the representative chemotherapy for managing respiratory distress calls for an obligatory deliberation for identifying the pharmaceuticals that effectively counter the contemporary intricacies associated with target disease. Multiple, complex regulatory pathways manifest chronic pulmonary disorders, which require chemotherapeutics that produce composite inhibitory effect. The cost effective natural product based molecules hold a high fervor to meet the prospects posed by current respiratory-distress therapy by sparing the tedious drug design and development archetypes, present a robust standing for the possible replacement of the fading practice of poly-pharmacology, and ensure the subversion of a potential disease relapse. This study summarizes the experimental evidences on natural products moieties and their components that illustrates therapeutic efficacy on respiratory disorders.
Original languageEnglish
Article number109125
Number of pages62
JournalChemico-Biological Interactions
Volume325
Early online date4 May 2020
DOIs
Publication statusPublished - 1 Jul 2020

Bibliographical note

Funding Information:
Philip M. Hansbro is supported by a fellowship from the National Health and Medical Research Council of Australia ( NHMRC # 1079187 ).

Funding Information:
Keshav Raj Paudel is supported by a fellowship from Prevent Cancer Foundation (PCF) and the International Association for the Study of Lung Cancer (IASLC) foundation, USA .

Funding Information:
Kamal Dua is supported by a project grant from Rebecca L. Cooper Medical Research Foundation and Sydney Partnership for Health, Education, Research and Enterprise (SPHERE) for the TRIPLE I CAG Secondment/Exchange grant.

Funding Information:
Meenu is supported by the Graduate School of Health and University of Technology Sydney (International Research Training Program Scholarship (IRTP)), Australia. Kamal Dua is supported by a project grant from Rebecca L. Cooper Medical Research Foundation and Sydney Partnership for Health, Education, Research and Enterprise (SPHERE) for the TRIPLE I CAG Secondment/Exchange grant. Philip M. Hansbro is supported by a fellowship from the National Health and Medical Research Council of Australia (NHMRC #1079187). Keshav Raj Paudel is supported by a fellowship from Prevent Cancer Foundation (PCF) and the International Association for the Study of Lung Cancer (IASLC) foundation, USA.

Publisher Copyright:
© 2020 Elsevier B.V.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • Alkaloids
  • COPD
  • Flavonoids
  • Natural products
  • Respiratory disorders

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