Prevalence of erectile dysfunction in male survivors of cancer: a systematic review and meta-analysis of cross-sectional studies

Damiano Pizzol, Tao Xiao, Lee Smith, Guillermo F López Sánchez, Andrea Garolla, Christopher Parris, Yvonne Barnett, Petre Cristian Ilie, Pinar Soysal, Jae Il Shin, Mark A Tully, Lin Yang, Nicola Veronese, Igor Grabovac

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Abstract

Background Prevalence of erectile dysfunction (ED) in male survivors of cancer across cancer types has not been systematically analysed.Aim To estimate the prevalence of ED in all types of cancer and identify characteristics associated with ED in survivors of cancer.Design and setting Systematic review and meta-analysis (MA) of cross-sectional studies.Method MEDLINE, CINAHL, PsycINFO, and EMBASE were searched, targeting reports published from inception to 1 February 2020. All retrospective or prospective studies reporting prevalence of ED in male patients with cancer and using a validated tool for detection of ED were included. A random-effects MA model was used to pool prevalence of ED as absolute estimates at three different stages, that is, ‘healthy’, ‘at diagnosis’, and ‘after treatment’. A univariate MA regression including the three-level group variable as the only independent variable was used to assess the difference in ED prevalence across the three groups. Further MAs were conducted for studies involving patients at diagnosis and after treatment, and statistical inferences were made with setting for multiple testing controlling for a false discovery rate (FDR) lt;0.05.Results In total, 1301 studies were assessed for inclusion. Of these, 141 were potentially eligible and subsequently scrutinised in full text. Finally, 43 studies were included with a total of 13 148 participants. Overall, pooled data of the included studies showed an ED prevalence of 40.7295CI] = 31.80 to 50.29) in patients with cancer, with prevalences of 28.60952.10 to 53.83) at time of diagnosis and 42.70952.97 to 53.03) after treatment, with significant difference between these two stages and across cancer locations, controlling for an FDR lt;0.05.Conclusion Erectile dysfunction was particularly high in male survivors of cancer and was associated with cancer treatment, cancer site, and age.
Original languageEnglish
Pages (from-to)e372-e380
Number of pages9
JournalBritish Journal of General Practice
Volume71
Issue number706
Early online date29 Apr 2021
DOIs
Publication statusPublished - 1 May 2021

Keywords

  • erectile dysfunction
  • male cancer
  • meta-analysis
  • systematic review
  • prevalence

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