Synthesis and characterisation of nanophase hydroxyapatite co-substitutedwith strontium and zinc

Naomi Lowry, Mark Brolly, Yisong Han, Stephen McKillop, Brian Meenan, Adrian Boyd

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35 Citations (Scopus)
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In order to develop new bioactive calcium phosphate (CaP) materials to repair bone defects, it is important to ensure these materials more closely mimic the non-stoichiometric nature of biological hydroxyapatite (HA). Typically, biological HA combines various CaP phases with different impurity ions, which substitute within the HA lattice, including strontium (Sr2+), zinc (Zn2+), magnesium (Mg2+), carbonate (CO32-) and fluoride (F-), but to name a few. In addition to this biological HA have dimensions in the nanometre (nm) range, usually 60 nm in length by 5–20 nm wide. Both the effects of ion substitution and the nano-size crystals are seen as important factors for enhancing their potential biofunctionality. The driving hypothesis was to successfully synthesise nanoscale hydroxyapatite (nHA), co-substituted with strontium (Sr2+) and zinc (Zn2+) ions in varying oncentrations using an aqueous precipitation method and to understand their chemical and physical properties. The materials were characterised using Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), X-Ray Photoelectron Spectroscopy (XPS) and Transmission Electron Microscopy (TEM) techniques. The FTIR, XRD and XPS results confirmed that the nHA was successfully co-substituted with Sr2+ and Zn2+, replacing Ca2+ within the nHA lattice at varying concentrations. The FTIR results confirmed that all of the samples were carbonated, with a significant loss of hydroxylation as a consequence of the incorporation of Sr2+ and Zn2+ into the nHA lattice. The TEM results showed that each sample produced was nano-sized, with the Sr/Zn-10% nHA having the smallest sized crystals approximately 17.6±3.3 nm long and 10.2±1.4 nm wide. None of the materials synthesised here in this study contained any other impurity CaP phases. Therefore, this study has shown that co-substituted nHA can be prepared, and that the degree of substitution (and the substituting ion) can have a profound effect on the attendant materials’ properties.
Original languageEnglish
Pages (from-to)7761-7770
JournalCeramics International
Issue number7
Early online date4 Feb 2018
Publication statusPublished - 31 May 2018

Bibliographical note

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  • Bioceramic
  • Nano-hydroxyapatite
  • Co-substitution
  • Strontium
  • Zinc


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